解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Aging is a natural and gradual process in human life. It is influenced by heredity, environment, lifestyle, and disease. DNA methylation varies with age, and the ability to predict the age of donor using DNA from evidence materials at a crime scene is of considerable value in forensic investigations. Recently, many st...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2017.50.11.175
更新日期:2017-11-01 00:00:00
abstract::Weight loss ≥ 5 percent is sufficient to significantly reduce health risks for obese people; therefore, development of novel weight loss compounds with reduced toxicity is urgently required. After screening of natural compounds with antiadipogenesis properties in 3T3-L1 cells, we determined that kahweol, a coffee-spec...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2017.50.11.031
更新日期:2017-11-01 00:00:00
abstract::Primed human pluripotent stem cells (hPSCs) are highly dependent on glycolysis rather than oxidative phosphorylation, which is similar to the metabolic switch that occurs in cancer cells. However, the molecular mechanisms that underlie this metabolic reprogramming in hPSCs and its relevance to pluripotency remain uncl...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2017.50.9.119
更新日期:2017-09-01 00:00:00
abstract::The Jun activation-domain binding protein 1 (Jab1) induces p53 nuclear export and cytoplasmic degradation, but the underlying mechanism is poorly understood. Here, we show that phosphorylation at the threonine 155 residue is essential for Jab1-mediated p53 nuclear export. Jab1 stimulated phosphorylation of p53 at T155...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2017.50.7.077
更新日期:2017-07-01 00:00:00
abstract::Monoacylglycerol acyltransferase 1 (MGAT) is a microsomal enzyme that catalyzes the synthesis of diacylglycerol (DAG) and triacylglycerol (TAG). However, the subcellular localization and catalytic function domain of this enzyme is poorly understood. In this report, we identified that murine MGAT1 localizes to the endo...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2017.50.7.036
更新日期:2017-07-01 00:00:00
abstract::Bone morphogenetic protein type 2 receptor (BMPR2) is one of the transforming growth factor-β (TGF-β) superfamily receptors, performing diverse roles during embryonic development, vasculogenesis, and osteogenesis. Human BMPR2 consists of 1,038 amino acids, and contains functionally conserved extracellular, transmembra...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2017.50.6.059
更新日期:2017-06-01 00:00:00
abstract::Advances in the understanding of the Hippo signaling as a key regulatory pathway of proliferation and apoptosis have provided mechanical insights for controlling organ size and tumorigenicity. Recently, much attention has been directed to the regulation of LATS1/2 (large tumor suppressor) kinases that phosphorylate YA...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2017.50.6.078
更新日期:2017-06-01 00:00:00
abstract::The biological activities of macrophage migration inhibitory factor (MIF) might be mediated through a classical receptormediated or non-classical endocytic pathway. JAB1 (C-Jun activation domain-binding protein-1) promotes the degradation of the tumor suppressor, p53, and the cyclin-dependent kinase inhibitor, p27. Wh...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2017.50.5.201
更新日期:2017-05-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is an essential cytokine that has functions in the formation of new blood vessels and regression of cardiac hypertrophy. VEGF/VEGF-receptor-1 (VEGFR1) signaling plays a key role in the regression of cardiac hypertrophy, whereas VEGF/VEGFR2 signaling leads to cardiac hypertroph...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2017.50.4.165
更新日期:2017-04-01 00:00:00
abstract::Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism ensuring the fast decay of mRNAs harboring a premature termination codon (PTC). As a quality control mechanism, NMD distinguishes PTCs from normal termination codons in order to degrade PTC-carrying mRNAs only. For this, NMD is connected to various other c...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2017.50.4.015
更新日期:2017-04-01 00:00:00
abstract::In embryonic stem cells (ESCs), cell cycle regulation is deeply connected to pluripotency. Especially, core transcription factors (CTFs) which are essential to maintaining the pluripotency transcription programs should be reset during M/G1 transition. However, it remains unknown about how CTFs are governed during cell...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2016.49.10.161
更新日期:2016-10-01 00:00:00
abstract::Glioma-Associated Oncogene Homolog1 (Gli1) is known to be activated in malignant glioma; however, its downstream pathway has not been fully explained. The aim of this study was to explore the role of Gli1-Aquaporin1 (AQP1) signal pathway in glioma cell survival. Our data suggests that both Gli1 and AQP1 are upregulate...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2016.49.7.011
更新日期:2016-07-01 00:00:00
abstract::Gene regulation in the brain is essential for long-term plasticity and memory formation. Despite this established notion, the quantitative translational map in the brain during memory formation has not been reported. To systematically probe the changes in protein synthesis during memory formation, our recent study exp...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2016.49.4.044
更新日期:2016-04-01 00:00:00
abstract::Liver cells experience hypoxic stress when drug-metabolizing enzymes excessively consume O2 for hydroxylation. Hypoxic stress changes the transcription of several genes by activating a heterodimeric transcription factor called hypoxia-inducible factor- 1α/β (HIF-1α/β). We found that hypoxic stress (0.1% O2) decreased ...
journal_title:BMB reports
pub_type: 新闻
doi:10.5483/bmbrep.2016.49.3.188
更新日期:2016-03-01 00:00:00
abstract::Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2016.49.2.261
更新日期:2016-02-01 00:00:00
abstract::The serine/threonine kinase mTOR is essential for the phosphoinositide 3-kinases (PI3K) signaling pathway, and regulates the development and function of immune cells. Aberrant activation of mTOR signaling pathway is associated with many cancers including leukemia. Here, we report the contributions of mTOR signaling to...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/BMBRep.2016.49.1.201
更新日期:2016-01-01 00:00:00
abstract::Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA. It stimulates pro-inflammatory cytokine and interferon production. Here we reported the expression of a novel isoform of TLR3 in human astrocyte cell lines whose message is generated by alternative splicing. The isoform represents the N-terminus of the ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.12.106
更新日期:2015-12-01 00:00:00
abstract::Downregulation of olfactomedin-4 (OLFM4) is associated with tumor progression, lymph node invasion and metastases. However, whether or not downregulation of OLFM4 is associated with epigenetic silencing remains unknown. In this study, we investigate the role of OLFM4 in gastric cancer cell invasion. We confirm the pre...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.11.130
更新日期:2015-11-01 00:00:00
abstract::Factors that modulate cholesterol levels have major impacts on cardiovascular disease. Niemann-Pick C1-like 1 (NPC1L1) functions as a sterol transporter mediating intestinal cholesterol absorption and counter-balancing hepatobiliary cholesterol excretion. The liver receptor homolog 1 (LRH-1) had been shown to regulate...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.9.253
更新日期:2015-09-01 00:00:00
abstract::The 12 kDa FK506-binding protein (FK506BP12), an immunosuppressor, modulates T cell activation via calcineurin inhibition. In this study, we investigated the ability of PEP-1-FK506BP12, consisting of FK506BP12 fused to the protein transduction domain PEP-1 peptide, to suppress catabolic responses in primary human chon...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.7.050
更新日期:2015-07-01 00:00:00
abstract::Hypoxia is associated with many pathological conditions as well as the normal physiology of metazoans. We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3). Oxygen negatively regulates NDRG3 expression at the protein level vi...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.6.080
更新日期:2015-06-01 00:00:00
abstract::Degenerative retinal diseases affect millions of people worldwide, which can lead to the loss of vision. However, therapeutic approaches that can reverse this process are limited. Recent efforts have allowed the possibility of the stem cell-based regeneration of retinal cells and repair of injured retinal tissues. Alt...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2015.48.4.276
更新日期:2015-04-01 00:00:00
abstract::Cardiac hypertrophy is a form of global remodeling, although the initial step seems to be an adaptation to increased hemodynamic demands. The characteristics of cardiac hypertrophy include the functional reactivation of the arrested fetal gene program, where histone deacetylases (HDACs) are closely linked in the devel...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.3.242
更新日期:2015-03-01 00:00:00
abstract::Tumor metastasis involves circulating and tumor-initiating capacities of metastatic cancer cells. Hepatic TM4SF5 promotes EMT for malignant growth and migration. Hepatocellular carcinoma (HCC) biomarkers remain unexplored for metastatic potential throughout metastasis. Here, novel TM4SF5/CD44 interaction-mediated self...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2015.48.3.047
更新日期:2015-03-01 00:00:00
abstract::The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent resear...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.12.193
更新日期:2014-12-01 00:00:00
abstract::The Ras/Raf/MEK/Erk signaling pathway is important for regulation of cell growth, proliferation, differentiation, survival, and apoptosis in response to a variety of extracellular stimuli. Lack of Erk MAPK activation is observed in several cancer cells despite active activation of Ras. However, little is known about t...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.12.017
更新日期:2014-12-01 00:00:00
abstract::As the prevalence of obesity has increased explosively over the last several decades, associated metabolic disorders, including type 2 diabetes, dyslipidemia, hypertension, and cardiovascular diseases, have been also increased. Thus, new strategies for preventing and treating them are needed. The nuclear peroxisome pr...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.11.174
更新日期:2014-11-01 00:00:00
abstract::All living cells release extracellular vesicles having pleiotropic functions in intercellular communication. Mammalian extracellular vesicles, also known as exosomes and microvesicles, are spherical bilayered proteolipids composed of various bioactive molecules, including RNAs, DNAs, proteins, and lipids. Extracellula...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.10.164
更新日期:2014-10-01 00:00:00
abstract::Oxidative stress and inflammation are common to many pathological conditions. Defense mechanisms protect cells from oxidative stress, but can become over-activated following injury and inflammation. NF-κB and Nrf2 transcription factors regulate proinflammatory and antioxidant gene expression, respectively. Studies hav...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.9.149
更新日期:2014-09-01 00:00:00
abstract::Cell therapies utilizing mesenchymal stem cells (MSCs) have a great potential in many research and clinical settings. The mechanisms underlying the therapeutic effects of MSCs have been studied previously and the paracrine effects elicited by their production of various growth factors and cytokines were recognized as ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.8.106
更新日期:2014-08-01 00:00:00
abstract::Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained....
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.8.159
更新日期:2014-08-01 00:00:00
abstract::Corn silk (CS) has long been consumed as a traditional herb in Korea. Maysin is a major flavonoid of CS. The effects of maysin on macrophage activation were evaluated, using the murine macrophage RAW 264.7 cells. Maysin was isolated from CS by methanol extraction, and preparative C18 reverse phase column chromatograph...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.7.191
更新日期:2014-07-01 00:00:00
abstract::Cohesin is a multi-protein complex composed of four core subunits (SMC1A, SMC3, RAD21, and either STAG1 or STAG2) that is responsible for the cohesion of sister chromatids following DNA replication until its cleavage during mitosis thereby enabling faithful segregation of sister chromatids into two daughter cells. Rec...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.6.092
更新日期:2014-06-01 00:00:00
abstract::Cancer cells undergo uncontrolled proliferation, and aberrant mitochondrial alterations. Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial heat shock protein. TRAP1 mRNA is highly expressed in some cancer cell lines and tumor tissues. However, the effects of its overexpression on mitochond...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.5.174
更新日期:2014-05-01 00:00:00
abstract::Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1. In this review, we discuss the role ...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.5.061
更新日期:2014-05-01 00:00:00
abstract::Ultraviolet B (UVB) radiation induces the production of reactive oxygen species (ROS) that promote apoptotic cell death. We showed that cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) plays an essential role in the control of cellular redox balance and defense against oxidative damage, by supplying NADPH for...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.4.137
更新日期:2014-04-01 00:00:00
abstract::Cell proliferation is a delicately regulated process that couples growth signals and metabolic demands to produce daughter cells. Interestingly, the proliferation of tumor cells immensely depends on glycolysis, the Warburg effect, to ensure a sufficient amount of metabolic flux and bioenergetics for macromolecule synt...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2014.47.3.273
更新日期:2014-03-01 00:00:00
abstract::Fibrin is a natural provisional matrix found in wound healing, while type I collagen is a major organic component of bone matrix. Despite the frequent use of fibrin and type I collagen in bone regenerative approaches, their comparative efficacies have not yet been evaluated. In the present study, we compared the effec...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.2.156
更新日期:2014-02-01 00:00:00
abstract::Znf45l, containing classical C2H2 domains, is a novel member of Zinc finger proteins in zebrafish. In vertebrates, TGF-β signaling plays a critical role in hematopoiesis. Here, we showed that Znf45l is expressed both maternally and zygotically throughout early development. Znf45l-depleted Zebrafish embryos display sho...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2014.47.1.048
更新日期:2014-01-01 00:00:00
abstract::Lipid droplet (LD) is a cellular organelle that stores neutral lipids as a source of energy and carbon. However, recent research has emerged that the organelle is involved in lipid synthesis, transportation, and metabolism, as well as mediating cellular protein storage and degradation. With the exception of multi-cell...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2013.46.12.271
更新日期:2013-12-01 00:00:00